Vancomycin lung penetration
SCOPE: A literature review was conducted to investigate the pharmacokinetics and pulmonary and tissue penetration of vancomycin and linezolid.
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30 Nov However, protein binding and limited penetration to sites of infection must . distribution and particularly lung penetration than vancomycin [28].
Description:The rising prevalence of nosocomial methicillin-resistant Staphylococcus aureus MRSA and the recent emergence of community-associated MRSA are major clinical, public health, and economic challenges. Vancomycin and linezolid are two commonly used antimicrobial agents with activity against Gram-positive pathogens, particularly MRSA, that are used to treat both nosocomial pneumonia and cSSTI. Recently, the therapeutic efficacy of vancomycin in the treatment of hospitalized patients with MRSA infections has been questioned due to the emergence of MRSA strains with reduced susceptibility to vancomycin together with concerns related to inadequate dosing and poor tissue penetration of the drug.
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